Hair Loss Treatment at the Proctor Clinic.
Hautarzt. 2013 Oct;64(10):762-7. doi: 10.1007/s00105-013-2597-y.
Spironolactone in dermatological treatment. On and off label indications.
Salavastru CM, Fritz K, Tiplica GS.
There are no currently FDA/EMEA-approved dermatologic indications for spironolactone and its off-label uses are, among others, female acne, female pattern hair loss, hidradenitis suppurativa or hirsutism. The rationale behind these relays on the mechanism of action of spironolactone which interferes with the hormone-controlled sebum and sweat gland secretion and with androgen stimulated hair growth. The average dose used by the dermatologits is 50-100 mg daily. It should not be used in pregnant and lactating women and it is not used in men due to the risk of feminization. Although further studies to assess its efficacy and safety are necessary, currently spironolactone is regarded as a useful tool in the dermatologic treatment armamentarium.
Targeted Photochemotherapy in Alopecia Areata
Photodermatol Photoimmunol Photomed. 2013 Sep 16. doi: 10.1111/phpp.12073.
Açikgöz G, et al
Alopecia areata (AA) is a common reason of localized non-scarring alopecia. Usage of targeted ultraviolet A (UVA) after the topical application of 8-methoxypsoralen (8-MOP) is one of the rising treatment modalities for AA. Our aim was to assess the efficacy and safety of topical 8-methoxypsoralen (8-MOP) plus targeted UVA phototherapy in the treatment of patchy AA.
Seven patchy AA patients were treated by topical 8-MOP application to the lesions followed by UVA irradiation 3 times a week, with a total session numbers of 15 to 24. At the end of the treatment all patients were evaluated for the response, on a 4 point scale (0= no hair, 1= white vellus hair, 2= regrowth cosmetically acceptable for the patient, 3= complete hair growth).
The mean cumulative UVA dose was 7.5 - 39.6 J/cm2 . For all 7 patients, average response score is calculated as 2, which means cosmetically acceptable regrowth.
“Targeted UVA phototherapy combined with topical 8-MOP'’ may be an effective and safe alternative treatment protocol for patchy AA, that should be kept in mind while choosing the best for the patients, especially for the patients incompatible for the other systemic and invasive treatments for hair loss.
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